Blood-Brain Barrier Dysfunction Precedes Cognitive Decline and Neurodegeneration in Diabetic Insulin Resistant Mouse Model: An Implication for Causal Link

Diabetic insulin resistance and pro-diabetic diet are reported to increase dementia risk through unknown mechanisms. Emerging evidence suggests that the integrity of blood-brain barrier (BBB) is central to the onset and progression of neurodegeneration and cognitive impairment. Therefore, the curren...

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Detalhes bibliográficos
Publicado no:Front Aging Neurosci
Main Authors: Takechi, Ryusuke, Lam, Virginie, Brook, Emily, Giles, Corey, Fimognari, Nicholas, Mooranian, Armin, Al-Salami, Hani, Coulson, Stephanie H., Nesbit, Michael, Mamo, John C. L.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2017
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5717019/
https://ncbi.nlm.nih.gov/pubmed/29249964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2017.00399
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