DNA methylation landscape of hepatoblastomas reveals arrest at early stages of liver differentiation and cancer-related alterations

Hepatoblastomas are uncommon embryonal liver tumors accounting for approximately 80% of childhood hepatic cancer. We hypothesized that epigenetic changes, including DNA methylation, could be relevant to hepatoblastoma onset. The methylomes of eight matched hepatoblastomas and non-tumoral liver tissu...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Maschietto, Mariana, Rodrigues, Tatiane Cristina, Kashiwabara, André Yoshiaki, de Araujo, Érica Sara Souza, Marques Aguiar, Talita Ferreira, da Costa, Cecilia Maria Lima, da Cunha, Isabela Werneck, dos Reis Vasques, Luciana, Cypriano, Monica, Brentani, Helena, de Toledo, Silvia Regina Caminada, Pearson, Peter Lees, Carraro, Dirce Maria, Rosenberg, Carla, Krepischi, Ana C.V.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5716698/
https://ncbi.nlm.nih.gov/pubmed/29228658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.14208
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