Z-disc protein CHAPb induces cardiomyopathy and contractile dysfunction in the postnatal heart

AIMS: The Z-disc is a crucial structure of the sarcomere and is implicated in mechanosensation/transduction. Dysregulation of Z-disc proteins often result in cardiomyopathy. We have previously shown that the Z-disc protein Cytoskeletal Heart-enriched Actin-associated Protein (CHAP) is essential for...

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Veröffentlicht in:PLoS One
Hauptverfasser: van Eldik, Willemijn, den Adel, Brigit, Monshouwer-Kloots, Jantine, Salvatori, Daniela, Maas, Saskia, van der Made, Ingeborg, Creemers, Esther E., Frank, Derk, Frey, Norbert, Boontje, Nicky, van der Velden, Jolanda, Steendijk, Paul, Mummery, Christine, Passier, Robert, Beqqali, Abdelaziz
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2017
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5716575/
https://ncbi.nlm.nih.gov/pubmed/29206857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0189139
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