Mechanistic insight into the assembly of the HerA–NurA helicase–nuclease DNA end resection complex

The HerA–NurA helicase–nuclease complex cooperates with Mre11 and Rad50 to coordinate the repair of double-stranded DNA breaks. Little is known, however, about the assembly mechanism and activation of the HerA–NurA. By combining hybrid mass spectrometry with cryo-EM, computational and biochemical da...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Ahdash, Zainab, Lau, Andy M., Byrne, Robert Thomas, Lammens, Katja, Stüetzer, Alexandra, Urlaub, Henning, Booth, Paula J., Reading, Eamonn, Hopfner, Karl-Peter, Politis, Argyris
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
Subjects:
Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5715905/
https://ncbi.nlm.nih.gov/pubmed/29149348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx890
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