In vivo measurements of interindividual differences in DNA glycosylases and APE1 activities

The integrity of our DNA is challenged with at least 100,000 lesions per cell on a daily basis. Failure to repair DNA damage efficiently can lead to cancer, immunodeficiency, and neurodegenerative disease. Base excision repair (BER) recognizes and repairs minimally helix-distorting DNA base lesions...

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Bibliographic Details
Published in:Proc Natl Acad Sci U S A
Main Authors: Chaim, Isaac A., Nagel, Zachary D., Jordan, Jennifer J., Mazzucato, Patrizia, Ngo, Le P., Samson, Leona D.
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2017
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PNAS Plus
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5715766/
https://ncbi.nlm.nih.gov/pubmed/29122935
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1712032114
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