The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline: possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis

BACKGROUND: Chemokine (C-C motif) ligand 1 (CCL1) is produced by activated monocytes/ macrophages and T-lymphocytes, and acts as a potent attractant for Th2 cells and a subset of T-regulatory (Treg) cells. Previous reports have indicated that CCL1 is overexpressed in adult T-cell leukemia cells, med...

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Detalhes bibliográficos
Publicado no:Virol J
Main Authors: Saito, Mineki, Sejima, Hiroe, Naito, Tadasuke, Ushirogawa, Hiroshi, Matsuzaki, Toshio, Matsuura, Eiji, Tanaka, Yuetsu, Nakamura, Tatsufumi, Takashima, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5715538/
https://ncbi.nlm.nih.gov/pubmed/29202792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12985-017-0902-6
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