Age-dependent increase of oxidative stress regulates microRNA-29 family preserving cardiac health

The short-lived turquoise killifish Nothobranchius furzeri (Nfu) is a valid model for aging studies. Here, we investigated its age-associated cardiac function. We observed oxidative stress accumulation and an engagement of microRNAs (miRNAs) in the aging heart. MiRNA-sequencing of 5 week (young), 12...

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Udgivet i:Sci Rep
Main Authors: Heid, Johanna, Cencioni, Chiara, Ripa, Roberto, Baumgart, Mario, Atlante, Sandra, Milano, Giuseppina, Scopece, Alessandro, Kuenne, Carsten, Guenther, Stefan, Azzimato, Valerio, Farsetti, Antonella, Rossi, Giacomo, Braun, Thomas, Pompilio, Giulio, Martelli, Fabio, Zeiher, Andreas M., Cellerino, Alessandro, Gaetano, Carlo, Spallotta, Francesco
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5715159/
https://ncbi.nlm.nih.gov/pubmed/29203887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16829-w
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