Aerobic exercise and a BDNF-mimetic therapy rescue learning and memory in a mouse model of Down syndrome

Down syndrome (DS) is caused by the triplication of human chromosome 21 and represents the most frequent genetic cause of intellectual disability. The trisomic Ts65Dn mouse model of DS shows synaptic deficits and reproduces the essential cognitive disabilities of the human syndrome. Aerobic exercise...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Parrini, Martina, Ghezzi, Diego, Deidda, Gabriele, Medrihan, Lucian, Castroflorio, Enrico, Alberti, Micol, Baldelli, Pietro, Cancedda, Laura, Contestabile, Andrea
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5715062/
https://ncbi.nlm.nih.gov/pubmed/29203796
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17201-8
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