Modelling Torsade de Pointes arrhythmias in vitro in 3D human iPS cell-engineered heart tissue

Torsade de Pointes (TdP) is a lethal arrhythmia that is often drug-induced, thus there is an urgent need for development of models to test or predict the drug sensitivity of human cardiac tissue. Here, we present an in vitro TdP model using 3D cardiac tissue sheets (CTSs) that contain a mixture of h...

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Pubblicato in:Nat Commun
Autori principali: Kawatou, Masahide, Masumoto, Hidetoshi, Fukushima, Hiroyuki, Morinaga, Gaku, Sakata, Ryuzo, Ashihara, Takashi, Yamashita, Jun K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5715012/
https://ncbi.nlm.nih.gov/pubmed/29057872
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-017-01125-y
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