Exendin-4 attenuates neuronal death via GLP-1R/PI3K/Akt pathway in early brain injury after subarachnoid hemorrhage in rats

Neuronal apoptosis is considered to be a crucial therapeutic target against early brain injury (EBI) after subarachnoid hemorrhage (SAH). Emerging evidence indicates that Exendin-4 (Ex-4), a glucagon-like peptide 1 receptor (GLP-1R) agonist, plays a neuroprotective role in cerebrovascular disease. T...

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Veröffentlicht in:Neuropharmacology
Hauptverfasser: Xie, Zhiyi, Enkhjargal, Budbazar, Wu, Lingyun, Zhou, Keren, Sun, Chengmei, Hu, Xin, Gospodarev, Vadim, Tang, Jiping, You, Chao, Zhang, John H.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5714662/
https://ncbi.nlm.nih.gov/pubmed/28986282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2017.09.040
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