A Functional ATG16L1 (T300A) Variant is Associated with Necrotizing Enterocolitis in Premature Infants

BACKGROUND: The genetic basis of dysfunctional immune responses in necrotizing enterocolitis (NEC) remains unknown. We hypothesized that variants in Nucleotide binding and Oligomerization Domain (NOD)-Like Receptors (NLRs) and Autophagy (ATG) genes modulate vulnerability to NEC. METHODS: We genotype...

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Gepubliceerd in:Pediatr Res
Hoofdauteurs: Sampath, Venkatesh, Bhandari, Vineet, Berger, Jessica, Merchant, Daniel, Zhang, Liyun, Ladd, Mihoko, Menden, Heather, Garland, Jeffery, Ambalavanan, Namasivayam, Mulrooney, Neil, Quasney, Michael, Dagle, John, Lavoie, Pascal M, Simpson, Pippa, Dahmer, Mary
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5714513/
https://ncbi.nlm.nih.gov/pubmed/27893720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/pr.2016.260
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