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Quantitating translational control: mRNA abundance-dependent and independent contributions and the mRNA sequences that specify them

Translation rate per mRNA molecule correlates positively with mRNA abundance. As a result, protein levels do not scale linearly with mRNA levels, but instead scale with the abundance of mRNA raised to the power of an ‘amplification exponent’. Here we show that to quantitate translational control, th...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Li, Jingyi Jessica, Chew, Guo-Liang, Biggin, Mark D.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5714229/
https://ncbi.nlm.nih.gov/pubmed/29040683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkx898
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