Phosphomimetic S3D cofilin binds but only weakly severs actin filaments

Many biological processes, including cell division, growth, and motility, rely on rapid remodeling of the actin cytoskeleton and on actin filament severing by the regulatory protein cofilin. Phosphorylation of vertebrate cofilin at Ser-3 regulates both actin binding and severing. Substitution of ser...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Elam, W. Austin, Cao, Wenxiang, Kang, Hyeran, Huehn, Andrew, Hocky, Glen M., Prochniewicz, Ewa, Schramm, Anthony C., Negrón, Karina, Garcia, Jean, Bonello, Teresa T., Gunning, Peter W., Thomas, David D., Voth, Gregory A., Sindelar, Charles V., De La Cruz, Enrique M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Molecular Biophysics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5712599/
https://ncbi.nlm.nih.gov/pubmed/28939776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.808378
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