Phosphomimetic S3D cofilin binds but only weakly severs actin filaments

Many biological processes, including cell division, growth, and motility, rely on rapid remodeling of the actin cytoskeleton and on actin filament severing by the regulatory protein cofilin. Phosphorylation of vertebrate cofilin at Ser-3 regulates both actin binding and severing. Substitution of ser...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Elam, W. Austin, Cao, Wenxiang, Kang, Hyeran, Huehn, Andrew, Hocky, Glen M., Prochniewicz, Ewa, Schramm, Anthony C., Negrón, Karina, Garcia, Jean, Bonello, Teresa T., Gunning, Peter W., Thomas, David D., Voth, Gregory A., Sindelar, Charles V., De La Cruz, Enrique M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2017
Pynciau:
Molecular Biophysics
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5712599/
https://ncbi.nlm.nih.gov/pubmed/28939776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.808378
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