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Identification of Clinically Approved Drugs Indacaterol and Canagliflozin for Repurposing to Treat Epidermal Growth Factor Tyrosine Kinase Inhibitor-Resistant Lung Cancer

In advanced lung cancer, epidermal growth factor tyrosine kinase inhibitors (EGFR TKIs) have extraordinary clinical efficacy. However, their usefulness is severely compromised by drug resistance mediated by various mechanisms, the most important of which is the secondary EGFR T790M mutation. The mut...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Front Oncol
Κύριοι συγγραφείς: Li, Hongjian, Tong, Christy Wing-Sum, Leung, Yee, Wong, Man-Hon, To, Kenneth Kin-Wah, Leung, Kwong-Sak
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Frontiers Media S.A. 2017
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5712561/
https://ncbi.nlm.nih.gov/pubmed/29238696
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2017.00288
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