Discrimination of germline EGFR T790M mutations in plasma cell-free DNA allows study of prevalence across 31,414 cancer patients

PURPOSE: Plasma cell-free DNA (cfDNA) analysis is increasingly used clinically for cancer genotyping, but may lead to incidental identification of germline risk alleles. We studied EGFR T790M mutations in non-small cell lung cancer (NSCLC) toward the aim of discriminating germline and cancer-derived...

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Detalhes bibliográficos
Publicado no:Clin Cancer Res
Main Authors: Hu, Yuebi, Alden, Ryan S., Odegaard, Justin I., Fairclough, Stephen R., Chen, Ruthia, Heng, Jennifer, Feeney, Nora, Nagy, Rebecca J., Shah, Jayshree, Ulrich, Bryan, Gutierrez, Martin, Lanman, Richard B., Garber, Judy E., Paweletz, Cloud P., Oxnard, Geoffrey R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5712272/
https://ncbi.nlm.nih.gov/pubmed/28947568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-17-1745
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