Hyperthyroidism, but not hypertension, impairs PITX2 expression leading to Wnt-microRNA-ion channel remodeling

PITX2 is a homeobox transcription factor involved in embryonic left/right signaling and more recently has been associated to cardiac arrhythmias. Genome wide association studies have pinpointed PITX2 as a major player underlying atrial fibrillation (AF). We have previously described that PITX2 expre...

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Vydáno v:PLoS One
Hlavní autoři: Lozano-Velasco, Estefanía, Wangensteen, Rosemary, Quesada, Andrés, Garcia-Padilla, Carlos, Osorio, Julia A., Ruiz-Torres, María Dolores, Aranega, Amelia, Franco, Diego
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2017
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5711019/
https://ncbi.nlm.nih.gov/pubmed/29194452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0188473
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