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Targeting The Tight Junction Protein, Zonula Occludens-1, With The Connexin 43 Mimetic Peptide, αCT1, Reduces VEGF-Dependent RPE Pathophysiology

A critical target tissue in age-related macular degeneration (AMD) is the retinal pigment epithelium (RPE), which forms the outer blood-retina barrier (BRB). RPE-barrier dysfunction might result from attenuation/disruption of intercellular tight junctions. Zonula occludens-1 (ZO-1) is a major struct...

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Detalles Bibliográficos
Publicado en:J Mol Med (Berl)
Main Authors: Obert, Elisabeth, Strauss, Randy, Brandon, Carlene, Grek, Christina, Ghatnekar, Gautam, Gourdie, Robert, Rohrer, Bärbel
Formato: Artigo
Idioma:Inglês
Publicado: 2017
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5710814/
https://ncbi.nlm.nih.gov/pubmed/28132078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-017-1506-8
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