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Bioequivalence Between Generic and Branded Lamotrigine in People With Epilepsy: The EQUIGEN Randomized Clinical Trial

IMPORTANCE: Switching between generic antiepileptic drugs is a highly debated issue that affects both clinical care and overall health care costs. OBJECTIVE: To evaluate the single-dose pharmacokinetic bioequivalence of 3 (1 branded and 2 generic drugs) on-market, immediate-release lamotrigine drug...

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Bibliographische Detailangaben
Veröffentlicht in:JAMA Neurol
Hauptverfasser: Berg, Michel, Welty, Timothy E., Gidal, Barry E., Diaz, Francisco J., Krebill, Ron, Szaflarski, Jerzy P., Dworetzky, Barbara A., Pollard, John R., Elder, Edmund J., Jiang, Wenlei, Jiang, Xiaohui, Switzer, Regina D., Privitera, Michael D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Medical Association 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5710324/
https://ncbi.nlm.nih.gov/pubmed/28654954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jamaneurol.2017.0497
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