Protein-lysine methyltransferases G9a and GLP1 promote responses to DNA damage

Upon induction of DNA breaks, ATM activation leads to a cascade of local chromatin modifications that promote efficient recruitment of DNA repair proteins. Errors in this DNA repair pathway lead to genomic instability and cancer predisposition. Here, we show that the protein lysine methyltransferase...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Ginjala, Vasudeva, Rodriguez-Colon, Lizahira, Ganguly, Bratati, Gangidi, Prawallika, Gallina, Paul, Al-Hraishawi, Husam, Kulkarni, Atul, Tang, Jeremy, Gheeya, Jinesh, Simhadri, Srilatha, Yao, Ming, Xia, Bing, Ganesan, Shridar
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5709370/
https://ncbi.nlm.nih.gov/pubmed/29192276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16480-5
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