Mitoxantrone, Etoposide, and Cytarabine (MEC) Following Epigenetic Priming with Decitabine in Adults with Relapsed/Refractory Acute Myeloid Leukemia or Other High-Grade Myeloid Neoplasms: A Phase 1/2 Study

DNA methyltransferase inhibitors sensitize leukemia cells to chemotherapeutics. We therefore conducted a phase 1/2 study of mitoxantrone, etoposide, and cytarabine following “priming” with 5-10 days of decitabine (dec/MEC) in 52 adults (median age 55 [range: 19-72] years) with relapsed/refractory ac...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Halpern, Anna B., Othus, Megan, Huebner, Emily M., Buckley, Sarah A., Pogosova-Agadjanyan, Era L., Orlowski, Kaysey F., Scott, Bart L., Becker, Pamela S., Hendrie, Paul C., Chen, Tara L., Percival, Mary-Elizabeth M., Estey, Elihu H., Stirewalt, Derek L., Walter, Roland B.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5709258/
https://ncbi.nlm.nih.gov/pubmed/28555084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/leu.2017.165
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