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The KISS1 metastasis suppressor appears to reverse the Warburg effect by shifting from glycolysis to mitochondrial beta-oxidation
The shift by cancer cells toward aerobic glycolysis (Warburg effect) confers selective advantages by utilizing nutrients (e.g. lipids, amino acids and nucleotides) to build biomass. Lipogenesis is generally enhanced and its inhibition diminishes proliferation and survival. Re-expression of the metas...
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| 出版年: | J Mol Med (Berl) |
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| 主要な著者: | , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2017
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5709182/ https://ncbi.nlm.nih.gov/pubmed/28597070 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00109-017-1552-2 |
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