Anexelekto/MER tyrosine kinase inhibitor ONO-7475 arrests growth and kills FMS-like tyrosine kinase 3-internal tandem duplication mutant acute myeloid leukemia cells by diverse mechanisms

Nearly one-third of patients with acute myeloid leukemia have FMS-like tyrosine kinase 3 mutations and thus have poor survival prospects. Receptor tyrosine kinase anexelekto is critical for FMS-like tyrosine kinase 3 signaling and participates in FMS-like tyrosine kinase 3 inhibitor resistance mecha...

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Udgivet i:Haematologica
Main Authors: Ruvolo, Peter P., Ma, Huaxian, Ruvolo, Vivian R., Zhang, Xiaorui, Mu, Hong, Schober, Wendy, Hernandez, Ivonne, Gallardo, Miguel, Khoury, Joseph D., Cortes, Jorge, Andreeff, Michael, Post, Sean M.
Format: Artigo
Sprog:Inglês
Udgivet: Ferrata Storti Foundation 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5709104/
https://ncbi.nlm.nih.gov/pubmed/28912176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2017.168856
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