Phosphoinositol-4,5-Bisphosphate Regulates Auditory Hair-Cell Mechanotransduction-Channel Pore Properties and Fast Adaptation

Membrane proteins, such as ion channels, interact dynamically with their lipid environment. Phosphoinositol-4,5-bisphosphate (PIP(2)) can directly or indirectly modify ion-channel properties. In auditory sensory hair cells of rats (Sprague Dawley) of either sex, PIP(2) localizes within stereocilia,...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Effertz, Thomas, Becker, Lars, Peng, Anthony W., Ricci, Anthony J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2017
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707765/
https://ncbi.nlm.nih.gov/pubmed/29066559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1351-17.2017
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