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Cytotoxicity of guanine-based degradation products contributes to the antiproliferative activity of guanine-rich oligonucleotides

Guanine-rich oligonucleotides (GROs) have attracted considerable attention as anticancer agents, because they exhibit cancer-selective antiproliferative activity and can form G-quadruplex structures with higher nuclease resistance and cellular uptake. Recently, a GRO, AS1411 has reached phase II cli...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Zhang, Nan, Bing, Tao, Liu, Xiangjun, Qi, Cui, Shen, Luyao, Wang, Linlin, Shangguan, Dihua
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707456/
https://ncbi.nlm.nih.gov/pubmed/29218153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c4sc03949a
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