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DHHC5-mediated palmitoylation of S1P receptor subtype 1 determines G-protein coupling

Sphingosine 1-phosphate (S1P) is a pleiotropic lipid mediator involved in the regulation of immune cell trafficking and vascular permeability acting mainly through G-protein-coupled S1P receptors (S1PRs). However, mechanism underlying how S1PRs are coupled with G-proteins remains unknown. Here we ha...

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Vydáno v:Sci Rep
Hlavní autoři: Badawy, Shaymaa Mohamed Mohamed, Okada, Taro, Kajimoto, Taketoshi, Ijuin, Takeshi, Nakamura, Shun-ichi
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707436/
https://ncbi.nlm.nih.gov/pubmed/29185452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16457-4
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