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Isotope effects in mechanistic studies of l-tyrosine halogen derivatives hydroxylation catalyzed by tyrosinase

The kinetic (KIE) and solvent (SIE) isotope effect methods were used to investigate the mechanism of enzymatic hydroxylation of halogenated derivatives of l-tyrosine to l-DOPA catalyzed by the enzyme tyrosinase (EC 1.14.18.1). The values of deuterium KIE and SIE were obtained using the non-competiti...

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Detalhes bibliográficos
Publicado no:J Radioanal Nucl Chem
Main Authors: Pająk, Małgorzata, Kańska, Marianna
Formato: Artigo
Idioma:Inglês
Publicado em: Springer Netherlands 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707235/
https://ncbi.nlm.nih.gov/pubmed/29213160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10967-017-5526-1
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