Gremlin Promotes Peritoneal Membrane Injury in an Experimental Mouse Model and Is Associated with Increased Solute Transport in Peritoneal Dialysis Patients

The peritoneal membrane becomes damaged in patients on peritoneal dialysis (PD). Gremlin 1 (GREM1) inhibits bone morphogenic proteins (BMPs) and plays a role in kidney development and fibrosis. We evaluated the role of gremlin in peritoneal fibrosis and angiogenesis. In a cohort of 32 stable PD pati...

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Détails bibliographiques
Publié dans:Am J Pathol
Auteurs principaux: Siddique, Imad, Curran, Simon P., Ghayur, Ayesha, Liu, Limin, Shi, Wei, Hoff, Catherine M., Gangji, Azim S., Brimble, K. Scott, Margetts, Peter J.
Format: Artigo
Langue:Inglês
Publié: American Society for Investigative Pathology 2014
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707198/
https://ncbi.nlm.nih.gov/pubmed/25194662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2014.07.018
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