Analysis of NPM1 splice variants reveals differential expression patterns of prognostic value in acute myeloid leukemia

Mutations of the nucleophosmin-1 (NPM1) gene in cytogenetically normal (CN) acute myeloid leukemia (AML) identify a group of patients with more favorable prognosis. NPM1 encodes three main alternatively spliced isoforms R1(B23.1), R2(B23.2), and R3(B23.3). The expression of splice variants R1, R2 an...

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Udgivet i:Oncotarget
Main Authors: Zajac, Malgorzata, Dolnik, Anna, Stasiak, Grazyna, Zaleska, Joanna, Kielbus, Michal, Czapinski, Jakub, Schunn, Matthias, Correa, Stephany C., Glodkowska-Mrowka, Eliza, Sundaram, Reddy Chakkarappan, Jankowska-Lecka, Olga, Schlenk, Richard F., Döhner, Hartmut, Döhner, Konstanze, Stepulak, Andrzej, Bullinger, Lars, Giannopoulos, Krzysztof
Format: Artigo
Sprog:Inglês
Udgivet: Impact Journals LLC 2017
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5707013/
https://ncbi.nlm.nih.gov/pubmed/29221119
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.19871
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