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KEAP1 has a sweet spot: A new connection between intracellular glycosylation and redox stress signaling in cancer cells
The KEAP1/NRF2 pathway is a master regulator of the redox stress response and is dysregulated in numerous human tumors. We discovered that NRF2 signaling is controlled by the site-specific glycosylation of KEAP1, revealing a potentially broad link among nutrient sensing, proteostasis and stress resi...
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| Publicado no: | Mol Cell Oncol |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Taylor & Francis
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5706953/ https://ncbi.nlm.nih.gov/pubmed/29209650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/23723556.2017.1361501 |
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