Combination of betulinic acid and chidamide inhibits acute myeloid leukemia by suppression of the HIF1α pathway and generation of reactive oxygen species

Acute myeloid leukemia (AML) is a heterogeneous disorder of the hematopoietic system with no common genetic “Achilles heel” that can be targeted. Most patients respond well to standard therapy, while a majority relapse, and development of an effective therapy for AML patients is still urgently neede...

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Dades bibliogràfiques
Publicat a:Oncotarget
Autors principals: Zhang, Hongyu, Li, Ling, Li, Min, Huang, Xiaodong, Xie, Weiguo, Xiang, Wei, Yao, Paul
Format: Artigo
Idioma:Inglês
Publicat: Impact Journals LLC 2017
Matèries:
Research Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5706909/
https://ncbi.nlm.nih.gov/pubmed/29212263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21889
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