Vorinostat and metformin sensitize EGFR-TKI resistant NSCLC cells via BIM-dependent apoptosis induction

There is a close relationship between low expression of BIM and resistance to epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). Vorinostat is a pan-histone deacetylase inhibitor (HDACi) that augments BIM expression in various types of tumor cells, however, this effect is attenua...

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Vydáno v:Oncotarget
Hlavní autoři: Chen, Hengyi, Wang, Yubo, Lin, Caiyu, Lu, Conghua, Han, Rui, Jiao, Lin, Li, Li, He, Yong
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2017
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5706838/
https://ncbi.nlm.nih.gov/pubmed/29212192
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21225
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