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The Natural Carotenoid Crocetin and the Synthetic Tellurium Compound AS101 Protect the Ovary against Cyclophosphamide by Modulating SIRT1 and Mitochondrial Markers

Cancer therapies are associated with increased infertility risk due to accelerated reproductive aging. Oxidative stress (OS) is a potential mechanism behind ovarian toxicity by cyclophosphamide (CPM), the most ovotoxic anticancer drug. An important sensor of OS is SIRT1, a NAD(+)-dependent deacetyla...

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Detalhes bibliográficos
Publicado no:Oxid Med Cell Longev
Main Authors: Di Emidio, Giovanna, Rossi, Giulia, Bonomo, Isabelle, Alonso, Gonzalo Luis, Sferra, Roberta, Vetuschi, Antonella, Artini, Paolo Giovanni, Provenzani, Alessandro, Falone, Stefano, Carta, Gaspare, D'Alessandro, Anna Maria, Amicarelli, Fernanda, Tatone, Carla
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5705900/
https://ncbi.nlm.nih.gov/pubmed/29270246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2017/8928604
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