Combination of Alcohol and Cigarette Smoke Induces Endoplasmic Reticulum Stress and Cell Death in Pancreatic Acinar Cells

BACKGROUND & AIMS: Smoking, an independent risk factor for pancreatitis, accelerates the development of alcoholic pancreatitis. Alcohol feeding of mice induces upregulation of spliced X-box binding protein 1 (XBP1s), which regulates the endoplasmic reticulum (ER) unfolded protein response and pr...

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Publicado en:Gastroenterology
Autores principales: Lugea, Aurelia, Gerloff, Andreas, Su, Hsin-Yuan, Xu, Zhihong, Go, Ariel, Hu, Cheng, French, Samuel W., Wilson, Jeremy S., Apte, Minoti V., Waldron, Richard T., Pandol, Stephen J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2017
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5705421/
https://ncbi.nlm.nih.gov/pubmed/28847752
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2017.08.036
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