The ceramide activated protein phosphatase Sit4 impairs sphingolipid dynamics, mitochondrial function and lifespan in a yeast model of Niemann-Pick type C1

The Niemann-Pick type C is a rare neurodegenerative disease that results from loss-of-function point mutations in NPC1 or NPC2, which affect the homeostasis of sphingolipids and sterols in human cells. We have previously shown that yeast lacking Ncr1, the orthologue of human NPC1 protein, display a...

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Bibliografiska uppgifter
I publikationen:Biochim Biophys Acta
Huvudupphovsmän: Vilaça, Rita, Barros, Ivo, Matmati, Nabil, Silva, Elísio, Martins, Telma, Teixeira, Vítor, Hannun, Yusuf A., Costa, Vítor
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2017
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC5705342/
https://ncbi.nlm.nih.gov/pubmed/28988886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2017.10.010
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