A specific missense mutation in GTF2I occurs at high frequency in thymic epithelial tumors

We analyzed 28 thymic epithelial tumors (TETs) using next-generation sequencing and identified a missense mutation (chromosome 7 c.74146970T>A) in GTF2I at high frequency in type A thymomas, a relatively indolent subtype. In a series of 274 TETs, we detected the GTF2I mutation in 82% of type A an...

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Publicat a:Nat Genet
Autors principals: Petrini, Iacopo, Meltzer, Paul S, Kim, In-Kyu, Lucchi, Marco, Park, Kang-Seo, Fontanini, Gabriella, Gao, James, Zucali, Paolo A, Calabrese, Fiorella, Favaretto, Adolfo, Rea, Federico, Rodriguez-Canales, Jaime, Walker, Robert L, Pineda, Marbin, Zhu, Yuelin J, Lau, Christopher, Killian, Keith J, Bilke, Sven, Voeller, Donna, Dakshanamurthy, Sivanesan, Wang, Yisong, Giaccone, Giuseppe
Format: Artigo
Idioma:Inglês
Publicat: 2014
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5705185/
https://ncbi.nlm.nih.gov/pubmed/24974848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3016
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