Asymmetric synthesis of propargylamines as amino acid surrogates in peptidomimetics

The amide moiety of peptides can be replaced for example by a triazole moiety, which is considered to be bioisosteric. Therefore, the carbonyl moiety of an amino acid has to be replaced by an alkyne in order to provide a precursor of such peptidomimetics. As most amino acids have a chiral center at...

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Pubblicato in:Beilstein J Org Chem
Autori principali: Wünsch, Matthias, Schröder, David, Fröhr, Tanja, Teichmann, Lisa, Hedwig, Sebastian, Janson, Nils, Belu, Clara, Simon, Jasmin, Heidemeyer, Shari, Holtkamp, Philipp, Rudlof, Jens, Klemme, Lennard, Hinzmann, Alessa, Neumann, Beate, Stammler, Hans-Georg, Sewald, Norbert
Natura: Artigo
Lingua:Inglês
Pubblicazione: Beilstein-Institut 2017
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Full Research Paper
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5704752/
https://ncbi.nlm.nih.gov/pubmed/29234470
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.13.240
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