Asparagine and glutamine ladders promote cross-species prion conversion

Prion transmission between species is governed in part by primary sequence similarity between the infectious prion aggregate, PrP(Sc), and the cellular prion protein of the host, PrP(C). A puzzling feature of prion formation is that certain PrP(C) sequences, such as that of bank vole, can be convert...

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Detaylı Bibliyografya
Yayımlandı:J Biol Chem
Asıl Yazarlar: Kurt, Timothy D., Aguilar-Calvo, Patricia, Jiang, Lin, Rodriguez, José A., Alderson, Nazilla, Eisenberg, David S., Sigurdson, Christina J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Biochemistry and Molecular Biology 2017
Konular:
Molecular Bases of Disease
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5704488/
https://ncbi.nlm.nih.gov/pubmed/28931606
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.794107
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