Mutation network-based understanding of pleiotropic and epistatic mutational behavior of Enterococcus faecalis FMN-dependent azoreductase

We previously identified a highly active homodimeric FMN-dependent NADH-preferred azoreductase (AzoA) from Enterococcus faecalis, which cleaves the azo bonds (R-N˭N-R) of diverse azo dyes, and determined its crystal structure. The preliminary network-based mutational analysis suggested that the two...

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Detalles Bibliográficos
Publicado en:Biochem Biophys Rep
Main Authors: Sun, Jinyan, Kweon, Ohgew, Jin, Jinshan, He, Gui-Xin, Li, Xiyu, Cerniglia, Carl E., Chen, Huizhong
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2017
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5704035/
https://ncbi.nlm.nih.gov/pubmed/29214224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrep.2017.10.008
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