Rational design of cholesterol oxidase for efficient bioresolution of cholestane skeleton substrates

Cholesterol oxidase catalyzes the oxidation and isomerization of the cholestane substrates leading to the addition of a hydroxyl group at the C3 position. Rational engineering of the cholesterol oxidase from Pimelobacter simplex (PsChO) was performed. Mutagenesis of V64 and F70 improved the catalyti...

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Detaylı Bibliyografya
Yayımlandı:Sci Rep
Asıl Yazarlar: Qin, Hui-Min, Zhu, Zhangliang, Ma, Zheng, Xu, Panpan, Guo, Qianqian, Li, Songtao, Wang, Jian-Wen, Mao, Shuhong, Liu, Fufeng, Lu, Fuping
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2017
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703901/
https://ncbi.nlm.nih.gov/pubmed/29180806
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-16768-6
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