Reduced Levels of the Synaptic Functional Regulator FMRP in Dentate Gyrus of the Aging Sprague-Dawley Rat

Fragile X mental retardation protein (FMRP) encoded by Fragile X mental retardation 1 (FMR1) gene is a RNA-binding regulator of mRNA translation, transport and stability with multiple targets responsible for proper synaptic function. Epigenetic silencing of FMR1 gene expression leads to the developm...

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Bibliografiske detaljer
Udgivet i:Front Aging Neurosci
Main Authors: Smidak, Roman, Sialana, Fernando J., Kristofova, Martina, Stojanovic, Tamara, Rajcic, Dragana, Malikovic, Jovana, Feyissa, Daniel D., Korz, Volker, Hoeger, Harald, Wackerlig, Judit, Mechtcheriakova, Diana, Lubec, Gert
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2017
Fag:
Neuroscience
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703695/
https://ncbi.nlm.nih.gov/pubmed/29218006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2017.00384
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