A universal mammalian vaccine cell line substrate

Using genome-wide small interfering RNA (siRNA) screens for poliovirus, influenza A virus and rotavirus, we validated the top 6 gene hits PV, RV or IAV to search for host genes that when knocked-down (KD) enhanced virus permissiveness and replication over wild type Vero cells or HEp-2 cells. The enh...

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Bibliografiske detaljer
Udgivet i:PLoS One
Main Authors: Murray, Jackelyn, Todd, Kyle V., Bakre, Abhijeet, Orr-Burks, Nichole, Jones, Les, Wu, Weilin, Tripp, Ralph A.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2017
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703543/
https://ncbi.nlm.nih.gov/pubmed/29176782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0188333
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