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Ultraaccurate genome sequencing and haplotyping of single human cells

Accurate detection of variants and long-range haplotypes in genomes of single human cells remains very challenging. Common approaches require extensive in vitro amplification of genomes of individual cells using DNA polymerases and high-throughput short-read DNA sequencing. These approaches have two...

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Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Chu, Wai Keung, Edge, Peter, Lee, Ho Suk, Bansal, Vikas, Bafna, Vineet, Huang, Xiaohua, Zhang, Kun
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703283/
https://ncbi.nlm.nih.gov/pubmed/29078313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1707609114
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