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Diminished Ost3-dependent N-glycosylation of the BiP nucleotide exchange factor Sil1 is an adaptive response to reductive ER stress

BiP (Kar2 in yeast) is an essential Hsp70 chaperone and master regulator of endoplasmic reticulum (ER) function. BiP’s activity is regulated by its intrinsic ATPase activity that can be stimulated by two different nucleotide exchange factors, Sil1 and Lhs1. Both Sil1 and Lhs1 are glycoproteins, but...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Stevens, Kofi L. P., Black, Amy L., Wells, Kelsi M., Yeo, K. Y. Benjamin, Steuart, Robert F. L., Stirling, Colin J., Schulz, Benjamin L., Mousley, Carl J.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5703277/
https://ncbi.nlm.nih.gov/pubmed/29109265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1705641114
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