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Microtubule-targeting agents can sensitize cancer cells to ionizing radiation by an interphase-based mechanism
BACKGROUND: The cytotoxic effects of microtubule-targeting agents (MTAs) are often attributed to targeted effects on mitotic cells. In clinical practice, MTAs are combined with DNA-damaging agents such as ionizing radiation (IR) with the rationale that mitotic cells are highly sensitive to DNA damag...
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| Udgivet i: | Onco Targets Ther |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Dove Medical Press
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5703169/ https://ncbi.nlm.nih.gov/pubmed/29200877 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S143096 |
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