Toosendanin demonstrates promising antitumor efficacy in osteosarcoma by targeting STAT3

Signal transducer and activator of transcription 3(STAT3) is an emerging target for cancer therapy. In this study, we identify Toosendanin (TSN) is an effective inhibitor of STAT3, leading to the impediment of various oncogenic processes in osteosarcoma. TSN selectively inactivates phospho-STAT3 (Ty...

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Dettagli Bibliografici
Pubblicato in:Oncogene
Autori principali: Zhang, T, Li, J, Yin, F, Lin, B, Wang, Z, Xu, J, Wang, H, Zuo, D, Wang, G, Hua, Y, Cai, Z
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2017
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5702716/
https://ncbi.nlm.nih.gov/pubmed/28783167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2017.270
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