A tricyclic pyrrolobenzodiazepine produced by Klebsiella oxytoca is associated with cytotoxicity in antibiotic-associated hemorrhagic colitis

Cytotoxin-producing Klebsiella oxytoca is the causative agent of antibiotic-associated hemorrhagic colitis (AAHC). Recently, the cytotoxin associated with AAHC was identified as tilivalline, a known pentacyclic pyrrolobenzodiazepine (PBD) metabolite produced by K. oxytoca. Although this assertion of...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Tse, Herman, Gu, Qiangshuai, Sze, Kong-Hung, Chu, Ivan K., Kao, Richard Y.-T., Lee, Kam-Chung, Lam, Ching-Wan, Yang, Dan, Tai, Sherlock Shing-Chiu, Ke, Yihong, Chan, Elaine, Chan, Wan-Mui, Dai, Jun, Leung, Sze-Pui, Leung, Suet-Yi, Yuen, Kwok-Yung
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5702686/
https://ncbi.nlm.nih.gov/pubmed/28972161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.791558
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