Activation of the phospholipid scramblase TMEM16F by nanosecond pulsed electric fields (nsPEF) facilitates its diverse cytophysiological effects

Nanosecond pulsed electric fields (nsPEF) are emerging as a novel modality for cell stimulation and tissue ablation. However, the downstream protein effectors responsible for nsPEF bioeffects remain to be established. Here we demonstrate that nsPEF activate TMEM16F (or Anoctamin 6), a protein functi...

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Publicat a:J Biol Chem
Autors principals: Muratori, Claudia, Pakhomov, Andrei G., Gianulis, Elena, Meads, Jade, Casciola, Maura, Mollica, Peter A., Pakhomova, Olga N.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2017
Matèries:
Cell Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5702676/
https://ncbi.nlm.nih.gov/pubmed/28982976
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.803049
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