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Panel‐based whole exome sequencing identifies novel mutations in microphthalmia and anophthalmia patients showing complex Mendelian inheritance patterns

BACKGROUND: Microphthalmia and anophthalmia (MA) are congenital eye abnormalities that show an extremely high clinical and genetic complexity. In this study, we evaluated the implementation of whole exome sequencing (WES) for the genetic analysis of MA patients. This approach was used to investigate...

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Detalhes bibliográficos
Publicado no:Mol Genet Genomic Med
Main Authors: Riera, Marina, Wert, Ana, Nieto, Isabel, Pomares, Esther
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5702572/
https://ncbi.nlm.nih.gov/pubmed/29178648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mgg3.329
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