In-vivo evaluation in rats of colon-specific microspheres containing 5-fluorouracil

The aims of this investigation were to determine the distribution in the gastrointestinal (GI) tract of Eudragit S-100 encapsulated colon-specific sodium alginate microspheres containing 5-fluorouracil (5-FU) in rats, and to perform pharmacokinetic and pharmacodynamic studies. Comparisons were with...

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Pubblicato in:J Pharm Pharmacol
Autori principali: Rahman, Ziyaur, Kohli, Kanchan, Zhang, Shuang-Qing, Khar, Roop K., Ali, Mushir, Charoo, Naseem A., Tauseef, Mohammad, Shamsher, Areeg A. A., Mohammed, Noorullah N., Repka, Michael A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701816/
https://ncbi.nlm.nih.gov/pubmed/18416938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1211/jpp.60.5.0007
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