Skin Delivery of Clec4a Small Hairpin RNA Elicited an Effective Antitumor Response by Enhancing CD8(+) Immunity In Vivo

Clec4a has been reported to be an immune suppressor of dendritic cells (DCs), but its potential role in cancer therapy remains to be elucidated. The present study investigated whether downregulating the expression of Clec4a via skin delivery of small hairpin RNA (shRNA) using a gene gun produced str...

Description complète

Enregistré dans:
Détails bibliographiques
Publié dans:Mol Ther Nucleic Acids
Auteurs principaux: Weng, Tzu-Yang, Li, Chia-Jung, Li, Chung-Yen, Hung, Yu-Hsuan, Yen, Meng-Chi, Chang, Yu-Wei, Chen, Yu-Hung, Chen, Yi-Ling, Hsu, Hui-Ping, Chang, Jang-Yang, Lai, Ming-Derg
Format: Artigo
Langue:Inglês
Publié: American Society of Gene & Cell Therapy 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701806/
https://ncbi.nlm.nih.gov/pubmed/29246320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2017.10.015
Tags: Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!

Documents similaires