Skin Delivery of Clec4a Small Hairpin RNA Elicited an Effective Antitumor Response by Enhancing CD8(+) Immunity In Vivo

Clec4a has been reported to be an immune suppressor of dendritic cells (DCs), but its potential role in cancer therapy remains to be elucidated. The present study investigated whether downregulating the expression of Clec4a via skin delivery of small hairpin RNA (shRNA) using a gene gun produced str...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Weng, Tzu-Yang, Li, Chia-Jung, Li, Chung-Yen, Hung, Yu-Hsuan, Yen, Meng-Chi, Chang, Yu-Wei, Chen, Yu-Hung, Chen, Yi-Ling, Hsu, Hui-Ping, Chang, Jang-Yang, Lai, Ming-Derg
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5701806/
https://ncbi.nlm.nih.gov/pubmed/29246320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2017.10.015
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